【佳学基因检测】ADRA1A等位基因突变会增加疾病的风险吗？

基因检测的序列名称：

ADRA1A

人体基因序列变化与疾病表征数据库中的基因代码：

148

人体基因序列数据库中国际交流名称全称

adrenoceptor alpha 1A

中国数据库中基因全称：肾上腺素受体1A基因检测报告英文版基因简介

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

基因突变所影响的基因信息

Alpha-1-肾上腺素受体（alpha-1-ARs）是G蛋白偶联受体超家族的成员。它们激活有丝分裂反应并调节许多细胞的生长和增殖。存在3种alpha-1-AR亚型：alpha-1A，-1B和-1D，它们均通过G蛋白的Gq / 11家族发出信号，不同的亚型显示出不同的激活模式。该基因编码α-1A-肾上腺素能受体。该基因的可变剪接产生四个转录物变体，其编码具有不同的C末端但具有相似的配体结合特性的四个不同的同工型。[由RefSeq提供，2008年7月]

国际国内该碱基因序列的其他英语文字母简称：

ADRA1C, ADRA1L1, ALPHA1AAR

基因解码对该基因序列在细胞核中的染色体所给予的编号：

该基因序列位于人类第8号染色体上。

基因解码对基因序列的精准定位

该基因序列在GRCh37版本中的起始位置坐标为：26605667；结束位置坐标为：26727003。该基因序列在GRCh38版本中的起始位置坐标为：26738113；结束位置坐标为：26870994。精准的基因信息定位是基因检测和对检测结果进行准确解读的关键。

佳学基因解码对该基因的功能分类：国际版

G-protein coupled receptors/GPCRs excl olfactory receptors

基因解码对该基因的功能分类：中文版

G 蛋白偶联受体/GPCR 不包括嗅觉受体

结构与功能基因解码所揭示的该基因在细胞内发挥作用的场所（国际版）：

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结构与功能基因解码所揭示的该基因发挥作用的细胞内位置（中文版）：

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该基因序列变化后增加的疾病风险（国际版）：

Ventricular Remodeling; Cannabis Dependence; cocaine use; Cocaine Abuse; Cocaine Dependence; Diabetes Mellitus, Experimental; Liver Cirrhosis; Unipolar Depression; Major Depressive Disorder; Bipolar Disorder; Schizophrenia

如果该基因突变后，风险可能增加的疾病类型（中文版）：

心室重塑；大麻依赖；使用可卡因；可卡因滥用；可卡因依赖；糖尿病实验性的；肝硬化；单极抑郁症；严重抑郁症;躁郁症;精神分裂症

GWAS基因检测所建立的与该基因的疾病关联（国际版）：

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GWAS基因检测所解码的该基因突变会增加风险的疾病种类（中文版）：

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以该基因做靶点的药物（国际版）：

Amphetamine (Protein heterodimerization activity);Midodrine (Protein heterodimerization activity);Citalopram (Protein heterodimerization activity);Ziprasidone (Protein heterodimerization activity);Cabergoline (Protein heterodimerization activity);Dapiprazole (Protein heterodimerization activity);Amitriptyline (Protein heterodimerization activity);Olanzapine (Protein heterodimerization activity);Alfuzosin (Protein heterodimerization activity);Clozapine (Protein heterodimerization activity);Norepinephrine (Protein heterodimerization activity);Mirtazapine (Protein heterodimerization activity);Mirtazapine (Protein heterodimerization activity);Phenylephrine (Protein heterodimerization activity);Phenylpropanolamine (Protein heterodimerization activity);Loxapine (Protein heterodimerization activity);Promazine (Protein heterodimerization activity);Dipivefrin (Protein heterodimerization activity);Droperidol (Protein heterodimerization activity);Prazosin (Protein heterodimerization activity);Imipramine (Protein heterodimerization activity);Chlorpromazine (Protein heterodimerization activity);Chlorpromazine (Protein heterodimerization activity);Nortriptyline (Protein heterodimerization activity);Amoxapine (Protein heterodimerization activity);Amoxapine (Protein heterodimerization activity);Clonidine (Protein heterodimerization activity);Doxazosin (Protein heterodimerization activity);Labetalol (Protein heterodimerization activity);Metaraminol (Protein heterodimerization activity);Nicardipine (Protein heterodimerization activity);Trazodone (Protein heterodimerization activity);Epinephrine (Protein heterodimerization activity);Thioridazine (Protein heterodimerization activity);Phentolamine (Protein heterodimerization activity);Ergotamine (Protein heterodimerization activity);Nicergoline (Protein heterodimerization activity);Tamsulosin (Protein heterodimerization activity);Methoxamine (Protein heterodimerization activity);Trimipramine (Protein heterodimerization activity);Risperidone (Protein heterodimerization activity);Epinastine (Protein heterodimerization activity);Propiomazine (Protein heterodimerization activity);Tolazoline (Protein heterodimerization activity);Fenoldopam (Protein heterodimerization activity);Trifluoperazine (Protein heterodimerization activity);Pseudoephedrine (Protein heterodimerization activity);Benzphetamine (Protein heterodimerization activity);Flupentixol (Protein heterodimerization activity);Phenoxybenzamine (Protein heterodimerization activity);Maprotiline (Protein heterodimerization activity);Oxymetazoline (Protein heterodimerization activity);Apraclonidine (Protein heterodimerization activity);Ergoloid mesylate (Protein heterodimerization activity);Promethazine (Protein heterodimerization activity);Carvedilol (Protein heterodimerization activity);Doxepin (Protein heterodimerization activity);Nefazodone (Protein heterodimerization activity);Desipramine (Protein heterodimerization activity);Terazosin (Protein heterodimerization activity);Escitalopram (Protein heterodimerization activity);Pergolide (Protein heterodimerization activity);Bromocriptine (Protein heterodimerization activity);Quetiapine (Protein heterodimerization activity);Aripiprazole (Protein heterodimerization activity);Ergonovine (Protein heterodimerization activity);Paliperidone (Protein heterodimerization activity);Bevantolol (Protein heterodimerization activity);Ephedrine (Protein heterodimerization activity);Mephentermine (Protein heterodimerization activity);Methotrimeprazine (Protein heterodimerization activity);4-Methoxyamphetamine (Protein heterodimerization activity);Dextroamphetamine (Protein heterodimerization activity);Phendimetrazine (Protein heterodimerization activity);Acepromazine (Protein heterodimerization activity);Thioproperazine (Protein heterodimerization activity);Zuclopenthixol (Protein heterodimerization activity);Dronedarone (Protein heterodimerization activity);Iloperidone (Protein heterodimerization activity);R450 (Protein heterodimerization activity);Epicept NP-1 (Protein heterodimerization activity);Sertindole (Protein heterodimerization activity);Mianserin (Protein heterodimerization activity);Silodosin (Protein heterodimerization activity);Asenapine (Protein heterodimerization activity);Droxidopa (Protein heterodimerization activity);Xylometazoline (Protein heterodimerization activity);Isometheptene (Protein heterodimerization activity);Levonordefrin (Protein heterodimerization activity);Naphazoline (Protein heterodimerization activity);Tetryzoline (Protein heterodimerization activity);Cirazoline (Protein heterodimerization activity)

针对该基因所产生的突变，可能有精准效果的药物（中文版）：

苯丙胺（蛋白质异二聚活性）；米多君（蛋白质异二聚活性）；西酞普兰（蛋白质异二聚活性）；齐拉西酮（蛋白质异二聚活性）；卡麦角林（蛋白质异二聚活性）；达哌唑（蛋白质异二聚活性）；阿米替林（蛋白质异二聚活性）；奥氮平(蛋白质异二聚活性);阿夫唑嗪(蛋白质异二聚活性);氯氮平(蛋白质异二聚活性);去甲肾上腺素(蛋白质异二聚活性);米氮平(蛋白质异二聚活性);米氮平(蛋白质异二聚活性);苯肾上腺素(蛋白质异二聚活性);苯丙醇胺(蛋白质异二聚活性);洛沙平(蛋白质异二聚活性);异丙嗪(蛋白质异二聚活性);地匹福林(蛋白质异二聚活性);氟哌利多(蛋白质异二聚活性);哌唑嗪(蛋白质异二聚活性);丙咪嗪(蛋白质异二聚活性);氯丙嗪(蛋白质异二聚活性)异二聚活性);氯丙嗪(蛋白质异二聚活性);去甲替林(蛋白质异二聚活性);阿莫沙平(蛋白质异二聚活性);阿莫沙平(蛋白质异二聚活性);可乐定(蛋白质异二聚活性);多沙唑嗪(蛋白质异二聚活性);拉贝洛尔(蛋白质异二聚活性)活性);间羟胺(蛋白质异二聚活性);尼卡地平(蛋白质异二聚活性);曲唑酮(蛋白质异二聚活性);肾上腺素(蛋白质异二聚活性);硫利达嗪(蛋白质异二聚活性);酚妥拉明(蛋白质异二聚活性);麦角胺(蛋白质异二聚活性) );尼麦角林(蛋白质异二聚活性);坦索罗辛(蛋白质异二聚活性);甲氧明(蛋白质异二聚活性);曲米帕明(蛋白质异二聚活性);利培酮(蛋白质异二聚活性);依匹斯汀(蛋白质异二聚活性);丙哌嗪(蛋白质异二聚活性) ;托拉唑啉（蛋白质异二聚活性）；非诺多泮（蛋白质异二聚活性）；三氟拉嗪（蛋白质异二聚活性）；伪麻黄碱（蛋白质异二聚活性）；苯丙胺（蛋白质异二聚活性）；氟哌噻吨（蛋白质异二聚活性）；苯氧苄胺（蛋白质异二聚活性）；马普替林（蛋白质异二聚化活性）；羟甲唑啉（蛋白质异二聚化活性）；安可乐定（蛋白质异二聚化活性）；麦角林甲磺酸盐（蛋白质异二聚化活性）；异丙嗪（蛋白质异二聚化活性）；卡维地洛（蛋白质异二聚化活性）；多虑平（蛋白质异二聚化活性）；奈法唑酮(蛋白质异二聚活性);地昔帕明(蛋白质异二聚活性);特拉唑嗪(蛋白质异二聚活性);艾司西酞普兰(蛋白质异二聚活性);培高利特(蛋白质异二聚活性);溴隐亭(蛋白质异二聚活性);喹硫平(蛋白质异二聚活性);阿立哌唑(蛋白质异二聚活性);麦角新碱(蛋白质异二聚活性);帕利哌酮(蛋白质异二聚活性);贝伐洛尔(蛋白质异二聚活性);麻黄碱(蛋白质异二聚活性);美芬特明(蛋白质异二聚活性);甲氧美拉嗪(蛋白质异二聚活性);4-甲氧苯丙胺(蛋白质异二聚活性);右旋苯丙胺(蛋白质异二聚活性);苯二甲曲嗪(蛋白质异二聚活性);乙酰丙嗪(蛋白质异二聚活性);硫丙哌嗪(蛋白质异二聚活性);珠氯噻醇(蛋白质异二聚活性);决奈达隆(蛋白质异二聚活性);伊潘立酮(蛋白质异二聚活性);R450(蛋白质异二聚活性);Epicept NP-1(蛋白质异二聚活性);Sertindole(蛋白质异二聚活性);米安色林(蛋白质异二聚活性);西洛多辛(蛋白质异二聚活性);阿塞那平(蛋白质异二聚活性) ;屈昔多巴（蛋白质异二聚化活性）;赛洛唑啉（蛋白质异二聚化活性）;异美汀（蛋白质异二聚化活性）;左旋诺德福林（蛋白质异二聚化活性）;萘甲唑啉（蛋白质异二聚化活性）;Tetryzoline（蛋白质异二聚化活性）;西拉唑啉（蛋白质异二聚化活性）

(责任编辑：佳学基因)