【佳学基因检测】血清微卫星分析检测食管腺癌

靶向药一个月费用排序

阅读肿瘤启动预防及复发抑制基因检测，在消化科肿瘤精准治疗专场听到《Eur J Surg Oncol》在. 2006 Nov;32(9):954-60.发表了一篇题目为《血清微卫星分析检测食管腺癌》肿瘤靶向药物治疗基因检测临床研究文章。该研究由C F Eisenberger , N H Stoecklein, S Jazra, S B Hosch, M Peiper, P Scheunemann, J Schulte Am Esch, W T Knoefel等完成。研究食管腺癌的早期预警、转移及复发特征的基因检测，是医学技术先进的大夫及医院选用的肿瘤基检测项目。

肿瘤靶向药物测序基因检测研究内容关键词：

血清,微卫星分析,基因检测,食管腺癌

肿瘤靶向治疗基因检测临床应用结果

食管腺癌肿瘤基因检测研究的背景与目的：器官局限型食管癌在许多患者中早期可以治愈，而更广泛的病变预后较差。我们试图通过使用一种新的分子方法开发一种用于癌症检测和评估患者预后的非侵入性测试。食管腺癌肿瘤基因检测研究的材料和方法：从 32 例腺癌患者中获得匹配的正常、肿瘤和血清样本。食管。提取 DNA 并使用 12 个标记对样品进行微卫星分析。来自 10 名健康个体的血清和正常样本作为对照。结果：32 名恶性肿瘤患者中有 27 名（84.4%）被发现在其原发肿瘤中有一个或多个微卫星 DNA 改变。通过微卫星分析，32 名患者中有 26 名（81.3%）的血清发生了改变。有趣的是，所有没有淋巴转移和三种早期癌（pT1pN0）的患者的血清中都显示出 LOH 改变，而来自正常对照受试者的所有血清 DNA 均为阴性。存活率与肿瘤中的 LOH 或血清中的 LOH 均无显着相关性。食管腺癌肿瘤基因检测研究的结论：这些数据表明，血清样本中的微卫星 DNA 分析可能为早期发现食管癌提供潜在的有价值的工具。循环肿瘤 DNA 的证据反映了这些肿瘤扩散到远处部位的倾向。到目前为止，随访时间仍然太短，无法就这一发现的预后影响得出进一步的结论。

肿瘤发生与复发转移国际数据库描述：

Background and aims: Organ-confined oesophageal cancer in an early stage can be cured in many patients, whereas more extensive lesions have a poor prognosis. We sought to develop a non-invasive test for cancer detection and evaluation of the prognosis of the patients by using a novel molecular approach.Material and methods: Matched normal-, tumour- and serum-samples were obtained from 32 patients with adenocarcinoma of the oesophagus. DNA was extracted and the samples were subjected to microsatellite analysis using 12 markers. Serum and normal samples from 10 healthy individuals served as controls.Results: Twenty-seven of the 32 patients (84.4%) with malignant tumours were found to have one or more microsatellite DNA alterations in their primary tumour. Twenty-six of the 32 patients (81.3%) had alterations in the serum by microsatellite analysis. Interestingly, all patients without lymphatic metastasis and three early carcinomas (pT1pN0) already displayed LOH alteration in the serum, while all serum DNA of samples from normal control subjects were negative. Survival was not significantly correlated with either LOH in the tumour or LOH in the serum.Conclusion: These data suggest that microsatellite DNA analysis in serum specimens might provide a potentially valuable tool for early detection of oesophageal cancer. The evidence of circulating tumour DNA reflects the propensity of these tumours to spread to distant sites. Up to now the follow-up is still too short to draw further conclusions on the prognostic impact of this finding.

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