【佳学基因检测】精神病学中的影像遗传学和基因组学：对进展和潜力的批判性回顾

全国十大基因检测公司排名简介

研讨神经系统基因组学个性化药物选择《精神与神经疾病致病基因突变位点的性质及影响分析》《Biol Psychiatry》在. 2017 Aug 1;82(3):165-175.发表了一篇题目为《精神病学中的影像遗传学和基因组学：对进展和潜力的批判性回顾》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Ryan Bogdan, Betty Jo Salmeron, Caitlin E Carey, Arpana Agrawal, Vince D Calhoun, Hugh Garavan, Ahmad R Hariri, Andreas Heinz, Matthew N Hill, Andrew Holmes, Ned H Kalin, David Goldman等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

遗传力、发病原因及精准治疗临床研究内容关键词：

神经科用药指导基因检测临床应用结果

影像遗传学和基因组学研究已经开始提供对神经表型的分子和遗传结构以及可能出现精神病理学遗传风险的神经机制的洞察。随着它接近第三个十年，成像遗传学面临着许多挑战，包括使用小样本量和不同设计的研究激增、复制有限、用于荟萃分析的神经表型协调问题、不清楚的机制以及影响大小的证据可能比最初假设的更温和，多基因性的证据越来越多。这些担忧促使该领域朝着许多新方向发展，包括发展联盟和大规模数据收集项目，以及使用新方法（例如，多基因方法、机器学习）来提高成像遗传研究的质量，同时也引入新的挑战。我们批判性地回顾了成像遗传学的进展，并提出了建议并强调了新方法的潜在缺陷。最终，成像遗传学和基因组学的优势在于它们与其他研究方法（例如，非人类动物模型、精神病学遗传学、药理学挑战）的转化和整合潜力，以阐明导致巨大个体行为差异的基于大脑的途径以及精神病理学的风险。关键词：候选人；遗传学；基因组学；成像；核磁共振；神经遗传学；多基因。

神经及精神疾病及其并发征、合并征国际数据库描述：

Imaging genetics and genomics research has begun to provide insight into the molecular and genetic architecture of neural phenotypes and the neural mechanisms through which genetic risk for psychopathology may emerge. As it approaches its third decade, imaging genetics is confronted by many challenges, including the proliferation of studies using small sample sizes and diverse designs, limited replication, problems with harmonization of neural phenotypes for meta-analysis, unclear mechanisms, and evidence that effect sizes may be more modest than originally posited, with increasing evidence of polygenicity. These concerns have encouraged the field to grow in many new directions, including the development of consortia and large-scale data collection projects and the use of novel methods (e.g., polygenic approaches, machine learning) that enhance the quality of imaging genetic studies but also introduce new challenges. We critically review progress in imaging genetics and offer suggestions and highlight potential pitfalls of novel approaches. Ultimately, the strength of imaging genetics and genomics lies in their translational and integrative potential with other research approaches (e.g., nonhuman animal models, psychiatric genetics, pharmacologic challenge) to elucidate brain-based pathways that give rise to the vast individual differences in behavior as well as risk for psychopathology.Keywords: Candidate; Genetics; Genomics; Imaging; MRI; Neurogenetics; Polygenic.

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