【佳学基因检测】从药物遗传学的起源到精神病学的首次应用

1年靶向药物要多少钱评价

探索神经系统基因检测中的数据库比对与基因解码明白《Pharmacopsychiatry》在. 2020 Jul;53(4):155-161.发表了一篇题目为《从药物遗传学的起源到精神病学的首次应用》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Daniel J Müller, Zoe Rizhanovsky等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

神经疾病遗传阻断及精准治疗临床研究内容关键词：

疾病修饰,癫痫,癫痫性脑病

精神科心理科疾病用药指导基因检测临床应用结果

药物遗传学是研究遗传因素如何影响给定药物的新陈代谢、反应和副作用的科学分支。曾经被认为是遗传学和药理学的一个分支，现在被认为是它自己的领域，并有自己独特的起源故事。虽然“药物遗传学”一词是由弗里德里希·沃格尔在 1959 年创造的，但早在很久以前就已经观察到遗传性遗传特征在影响外源性临床结果方面的相关性。事实上，很有希望药物遗传学可以帮助解开“谜团”，即为什么不同的人可能对相同的药物表现出不同的反应以及识别新的药物靶点。本文将重点介绍由先驱科学家 Arno Motulsky 和 Friedrich Vogel（均为人类遗传学家）以及 Werner Kalow（临床药理学家）提出的药物遗传学概念框架，这些框架促成了现代药物遗传学的诞生。最后，回顾了当前精神治疗的实际意义和实施的第一步，然后对未来的研究进行了展望。

神经及精神疾病及其并发征、合并征国际数据库描述：

Pharmacogenetics is the division of science addressing how genetic factors contribute to the metabolism, response, and side effects of a given medication. What was once regarded as a subdivision of genetics and pharmacology is now recognized as its own field and has its own unique story of origin. While the term "pharmacogenetics" was coined by Friedrich Vogel in 1959, the relevance of inherited genetic traits in affecting the clinical outcome to xenobiotics has been observed long before. In fact, there is much hope that pharmacogenetics can help unravel the "mysteries" as to why different people may display variable responses to the same medication as well as identify new drug targets. This article will highlight the conceptual framework for pharmacogenetics advanced by pioneer scientists Arno Motulsky and Friedrich Vogel (both human geneticists), as well as Werner Kalow (clinical pharmacologist), leading up to the creation of modern pharmacogenetics. Finally, the practical implications and first steps toward implementation for current psychiatric treatment are reviewed followed by an outlook on future studies.

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