【佳学基因检测】吸毒成瘾：一种可治愈的精神障碍？

精神病基因检测19800元导读

根据精神病治疗的前沿研究知道《Acta Pharmacol Sin》在. 2018 Dec;39(12):1823-1829.发表了一篇题目为《吸毒成瘾：一种可治愈的精神障碍？》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Jian-Feng Liu, Jun-Xu Li等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

遗传力、发病原因及精准治疗临床研究内容关键词：

生物标志物,遗传学

神经科用药指导基因检测临床应用结果

吸毒成瘾是一种慢性、反复发作的脑部疾病。大脑中的多个神经网络，包括奖赏系统（例如，中脑边缘系统）、抗奖赏/压力系统（例如，扩展的杏仁核）和中枢免疫系统，都参与了药物成瘾和吸毒后复发的发展。戒除滥用药物。临床前和临床研究表明，通过药理学靶向大脑中与成瘾相关的系统来控制药物成瘾是有希望的。在这里，我们回顾了具有临床意义的多巴胺系统、谷氨酸系统、微量胺系统、抗奖赏系统和中枢免疫系统内的药理学靶点。此外，我们讨论了其他潜在的疗法，例如脑刺激、行为疗法和治疗性基因调节，它们可能对治疗药物成瘾有效。我们的结论是，虽然吸毒成瘾是一种复杂的疾病，涉及复杂的神经机制和心理过程，但这种精神疾病是可以治疗的，未来可能通过基因调控等疗法治愈。脑刺激；吸毒成瘾；基因治疗;药理靶点。

神经及精神疾病及其并发征、合并征国际数据库描述：

Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain including the reward system (e.g., the mesocorticolimbic system), the anti-reward/stress system (e.g., the extended amygdala), and the central immune system, are involved in the development of drug addiction and relapse after withdrawal from drugs of abuse. Preclinical and clinical studies have demonstrated that it is promising to control drug addiction by pharmacologically targeting the addiction-related systems in the brain. Here we review the pharmacological targets within the dopamine system, glutamate system, trace amine system, anti-reward system, and central immune system, which are of clinical interests. Furthermore, we discuss other potential therapies, e.g., brain stimulation, behavioral treatments, and therapeutic gene modulation, which could be effective to treat drug addiction. We conclude that, although drug addiction is a complex disorder that involves complicated neural mechanisms and psychological processes, this mental disorder is treatable and may be curable by therapies such as gene modulation in the future.Keywords: behavioral treatment; brain stimulation; drug addiction; gene therapy; pharmacological targets.

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