【佳学基因检测】全基因组时代饮食失调的遗传学

神经内科基因检测的费用大概多少钱引言

研究癌症的早期发现及检测获悉《Psychol Med》在. 2021 Oct;51(13):2287-2297.发表了一篇题目为《全基因组时代饮食失调的遗传学》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Hunna J Watson, Alish B Palmos, Avina Hunjan, Jessica H Baker, Zeynep Yilmaz, Helena L Davies等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

神经疾病遗传阻断及正确治疗临床研究内容关键词：

精神科心理科疾病用药指导基因检测临床应用结果

得益于高通量基因组测序的进步和前所未有的全球数据共享水平，分子遗传学研究开始揭示饮食失调的生物学基础。这篇特邀综述概述了全基因组时代饮食失调的基因发现。迄今为止，已经进行了五项关于饮食失调的全基因组关联研究——全部针对神经性厌食症 (AN)。对于 AN，已检测到几个风险位点，约 11-17% 的遗传力是由常见的遗传变异引起的。 AN 与心理特征之间存在广泛的遗传重叠，尤其是强迫症，有趣的是，即使在调整了体重指数 (BMI) 风险变异后，其代谢表型也存在。此外，易导致 BMI 降低的遗传风险变异可能是 AN 的因果风险因素。饮食失调的因果基因和生物学途径尚未阐明，需要更大的样本量和统计能力以及功能性后续研究。正在进行几项研究以招募患有神经性贪食症和暴食症的个体，以进行进一步的全基因组研究。专注于饮食失调遗传学的数据收集和研究实验室已与精神病基因组学联盟一起在全球范围内开展工作。全基因组时代的分子遗传学研究正在提高人们对已确定的饮食失调遗传力背后生物学的认识。这有可能为理解饮食失调的病因和克服饮食失调领域面临的治疗挑战提供新的希望。遗传学；全基因组关联研究；审查。

神经及精神疾病及其并发征、合并征国际数据库描述：

Enabled by advances in high throughput genomic sequencing and an unprecedented level of global data sharing, molecular genetic research is beginning to unlock the biological basis of eating disorders. This invited review provides an overview of genetic discoveries in eating disorders in the genome-wide era. To date, five genome-wide association studies on eating disorders have been conducted - all on anorexia nervosa (AN). For AN, several risk loci have been detected, and ~11-17% of the heritability has been accounted for by common genetic variants. There is extensive genetic overlap between AN and psychological traits, especially obsessive-compulsive disorder, and intriguingly, with metabolic phenotypes even after adjusting for body mass index (BMI) risk variants. Furthermore, genetic risk variants predisposing to lower BMI may be causal risk factors for AN. Causal genes and biological pathways of eating disorders have yet to be elucidated and will require greater sample sizes and statistical power, and functional follow-up studies. Several studies are underway to recruit individuals with bulimia nervosa and binge-eating disorder to enable further genome-wide studies. Data collections and research labs focused on the genetics of eating disorders have joined together in a global effort with the Psychiatric Genomics Consortium. Molecular genetics research in the genome-wide era is improving knowledge about the biology behind the established heritability of eating disorders. This has the potential to offer new hope for understanding eating disorder etiology and for overcoming the therapeutic challenges that confront the eating disorder field.Keywords: Eating disorders; genetics; genome-wide association studies; review.

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