【佳学基因检测】线粒体转运蛋白在癌症中的表达和推测作用

肿瘤基因检测多少钱一次—目标

在基因检测小组讨论中，得知《肿瘤致病基因突变位点的性质及影响分析》《Biochim Biophys Acta Bioenerg》在 2017 Aug;1858(8):641-654发表了一篇题目为《线粒体转运蛋白在癌症中的表达和推测作用》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Oleksandr Lytovchenko, Edmund R S Kunji 等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及精准治疗临床研究内容关键词：

癌症代谢,线粒体载体,线粒体代谢,丙酮酸载体,癌症调节,运输者。

肿瘤靶向治疗基因检测临床应用结果

癌细胞在能量和生物合成代谢方面发生重大变化。其中之一是 Warburg 效应，其中丙酮酸用于发酵而不是氧化磷酸化。另一个主要问题是他们对谷氨酰胺的依赖增加，这有助于补充用于其他目的的克雷布斯循环代谢物库，例如氨基酸或脂质生物合成。线粒体是这些改变的核心，因为连接这些过程的生化途径贯穿这些细胞器。两个膜，一个外膜和一个内膜，围绕着线粒体，后者对大多数有机化合物是不可渗透的。因此，需要大量的转运蛋白来连接胞质溶胶和线粒体基质的生化途径。由于运输步骤相对缓慢，预计当细胞癌变时，许多运输步骤会发生改变。在这篇综述中，讨论了这些转运蛋白的表达和调控的变化以及转运底物的作用。本文是由 Giuseppe Gasparre、Rodrigue Rossignol 和 Pierre Sonveaux 编辑的题为“癌症中的线粒体”的特刊的一部分。

肿瘤发生与复发转移国际数据库描述：

Cancer cells undergo major changes in energy and biosynthetic metabolism. One of them is the Warburg effect, in which pyruvate is used for fermentation rather for oxidative phosphorylation. Another major one is their increased reliance on glutamine, which helps to replenish the pool of Krebs cycle metabolites used for other purposes, such as amino acid or lipid biosynthesis. Mitochondria are central to these alterations, as the biochemical pathways linking these processes run through these organelles. Two membranes, an outer and inner membrane, surround mitochondria, the latter being impermeable to most organic compounds. Therefore, a large number of transport proteins are needed to link the biochemical pathways of the cytosol and mitochondrial matrix. Since the transport steps are relatively slow, it is expected that many of these transport steps are altered when cells become cancerous. In this review, changes in expression and regulation of these transport proteins are discussed as well as the role of the transported substrates. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.

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