【佳学基因检测】CRISPR/Cas9 引导的表观遗传调控对神经精神疾病的潜在治疗意义

靶向药一个月费用排序

阅读神经系统启动预防及复发抑制基因检测听到《Curr Top Med Chem》在. 2021;21(10):878-894.发表了一篇题目为《CRISPR/Cas9 引导的表观遗传调控对神经精神疾病的潜在治疗意义》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Desh D Singh, Ravi Verma, Piyush Parimoo, Ashish Sahu, Vikram Kumar, Era Upadhyay, Dharmendra K Yadav等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

精神科神经科致病基因及精准治疗临床研究内容关键词：

GWAS,动物模型,双极,会聚功能基因组学,基因表达

精神科心理科疾病用药指导基因检测临床应用结果

脑功能活动受遗传和表观遗传因素的几种机制的调节，例如组蛋白建模、DNA 甲基化和非编码 RNA。这些调节机制的改变会影响导致神经精神疾病 (ND) 的神经元的正常发育。然而，需要分析与分子机制相关的神经精神疾病的功能意义，以在患者的早期诊断和治疗中带来治疗进展。 CRISPR/Cas 9（Clustered Regularly Interspaced Short Palindromic Repeats）基因组编辑工具同时彻底改变了多个基因组和表观基因组操作目标。本综述讨论了在 ND 的分子机制中使用 CRISPR/Cas 9 工具作为一种治疗方法来克服由遗传和表观遗传异常引起的 ND 的可能性。表观遗传规律；基因编辑；神经元发育；神经精神疾病；治疗应用。转录因子。

神经及精神疾病及其并发征、合并征国际数据库描述：

Brain function activity is regulated by several mechanisms of genetic and epigenetic factors such as histone modelling, DNA methylation, and non-coding RNA. Alterations in these regulatory mechanisms affect the normal development of neurons that causes Neuropsychiatric Disorders (ND). However, it is required to analyse the functional significance of neuropsychiatric disorders associated with a molecular mechanism to bring about therapeutic advances in early diagnosis and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation targets the same time. This review discussed the possibilities of using CRISPR/Cas 9 tools during molecular mechanism in the ND as a therapeutic approach to overcome ND that is caused due to genetic and epigenetic abnormalities.Keywords: CRISPR/Cas9; Epigenetic regulations; Gene editing; Neuronal development; Neuropsychiatric Disorders; Therapeutic applications.; Transcription factor.

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