【佳学基因检测】精神病学遗传学史前史：1780-1910

基因测序的费用大概多少钱省钱要点

查重分析高效抑制神经科疾病转移的方法与药物《精神与神经疾病致病基因突变位点的性质及影响分析》《Am J Psychiatry》在. 2021 Jun;178(6):490-508.发表了一篇题目为《精神病学遗传学史前史：1780-1910》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Kenneth S Kendler等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

神经疾病遗传阻断及精准治疗临床研究内容关键词：

神经科用药指导基因检测临床应用结果

虽然精神遗传学已成为我们最具活力的研究领域之一，但我们看待这些发展的历史背景是有限的。为了提供这样的视角，作者回顾了 1780 年至 1910 年间出版的 48 篇代表性文本，考察了精神错乱的遗传。出现了六个主要结论。首先，大多数作者认为遗传是精神错乱的最强风险因素之一。其次，大多数作者得出结论认为，疾病倾向而不是疾病本身是在家庭中传播的。第三，人们注意到了传播的概率性质，因为精神错乱通常会跨越几代人或仅影响许多兄弟姐妹中的少数人。第四，作者讨论了各种形式的精神错乱的家庭传播的同质性与异质性。异质性传播通常被视为患有各种精神疾病，有时甚至是神经疾病的精神病患者的亲属的规则。同质传输（“like begets like”）是个例外。第五，作者指出，古怪和古怪的人格特征在精神病患者的亲属中很常见。最后，遗传通常被理解为包括父母先前的环境经历，一些作者指出，精神错乱的父母-后代传播可能来自心理或宫内影响。许多这些结论仅来自临床经验，没有对生物学机制、统计分析或必要控制的理解，得到了后来更严格的方法的支持。与其完全拒绝它的价值，我们可能会将这些文献视为一种补充资源，可能更有偏见，但充斥着我们前辈广泛的临床知识。精神病学遗传学。

神经及精神疾病及其并发征、合并征国际数据库描述：

While psychiatric genetics has emerged as one of our most dynamic research fields, the historical context in which we view these developments is limited. To provide such a perspective, the author reviews 48 representative texts, published from 1780 to 1910, examining the inheritance of insanity. Six main conclusions emerge. First, most authors viewed heredity as among the strongest risk factors for insanity. Second, most writers concluded that a predisposition to illness rather than the illness itself was transmitted in families. Third, the probabilistic nature of the transmission was noted, as insanity often skipped generations or affected only a few of many siblings. Fourth, authors discussed the homogeneity versus heterogeneity of familial transmission of the various forms of insanities. Heterogeneous transmission was usually seen as the rule-with relatives of insane patients affected with a wide variety of psychiatric, and sometimes neurological, illnesses. Homogeneous transmission ("like begets like") was the exception. Fifth, writers noted that odd and eccentric personality features were common in the relatives of their insane patients. Finally, inheritance was commonly understood to include prior environmental parental experiences, and some authors noted that parent-offspring transmission of insanity could arise from psychological or intrauterine effects. Many of these conclusions, arising solely from clinical experience and without an understanding of biological mechanisms, statistical analyses, or necessary controls, are supported by later, more rigorous methods. Rather than entirely rejecting its value, we might view this literature as a complementary resource, likely more biased, but suffused with the extensive clinical knowledge of our forebears.Keywords: History of Psychiatry; Psychiatric Genetics.

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