【佳学基因检测】黑腹果蝇肿瘤抑制基因致死 (2) 肿瘤成像盘 (1(2)tid) 的遗传、细胞遗传学和发育分析

基因检测多少钱一次1万八解剖

与专家交流肿瘤个性化药物研究路径发现《Differentiation》在. 1992 Oct;51(2):91-104.发表了一篇题目为《黑腹果蝇肿瘤抑制基因致死 (2) 肿瘤成像盘 (1(2)tid) 的遗传、细胞遗传学和发育分析》肿瘤靶向药物治疗基因检测临床研究文章。该研究由U Kurzik-Dumke, B Phannavong, D Gundacker, E Gateff等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及精准治疗临床研究内容关键词：

肿瘤靶向治疗基因检测临床应用结果

果蝇的二十个隐性致死肿瘤抑制基因中的三个在纯合突变状态下引起想象盘肿瘤。其中之一是致命的（2）肿瘤成虫盘（l（2）tid）基因。组织学检查显示肿瘤性成虫盘上皮由单层细胞镶嵌和成簇排列的细胞组成。相反，野生型成虫盘上皮仅由单层排列的细胞组成。植入准备蛹化的野生型幼虫的突变体成虫盘组织片无法区分。将l(2)tid 成像盘组织片体内植入野生型成蝇体内，发现与原位相当的致死性肿瘤生长，因此将l(2)tid 成像盘定性为真正的恶性。描述和讨论了两个 l(2)tid 等位基因和肿瘤抑制基因之间的双突变体的表型，例如致命的 (2) 巨型幼虫和致命的 (2) 脑肿瘤，以及上皮过度生长突变体致命的 (2) 脂肪。最后，基因解码基因检测将 l(2)tid 基因的遗传、细胞遗传学和分子定位介绍到巨大的染色体带 59F4-6。

肿瘤发生与复发转移国际数据库描述：

Three of the twenty recessive-lethal tumor suppressor genes of Drosophila cause imaginal disc tumors in the homozygously mutated state. One of these is the lethal(2)tumorous imaginal discs (l(2)tid) gene. Histological preparations show the tumorous imaginal disc epithelium to consist of a mosaic of cells in monolayer and cells in clumped arrangement. In contrast, the wild-type imaginal disc epithelium is comprised exclusively of cells in monolayer arrangement. Mutant imaginal disc tissue pieces implanted into ready-to-pupariate wild-type larvae fail to differentiate. Implantation of l(2)tid imaginal disc tissue pieces in vivo into wild-type adult flies revealed a lethal, tumorous growth comparable to that in situ, thus characterizing the l(2)tid imaginal discs as truly malignant. The phenotypes of double mutants between two l(2)tid alleles and tumor suppressor genes, such as lethal(2)giant larvae and lethal(2)brain tumor, and the epithelial overgrowth mutant lethal(2)fat are described and discussed. Finally, we present the genetic, cytogenetic and molecular localization of the l(2)tid gene to the giant chromosome bands 59F4-6.

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