【佳学基因检测】基因检测揭示乳腺癌中肿瘤抑制基因的致癌机制

靶向药基因检测两万有必要吗—标准

与专家交流知道《Int J Mol Sci》在. 2022 Aug 25;23(17):9624.发表了一篇题目为《揭示乳腺癌多组学数据中肿瘤抑制基因的致癌机制》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Seong Beom Cho 等完成。促进了肿瘤的精准治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及精准治疗临床研究内容关键词：

乳腺癌,多组学数据,监管机制,抑癌基因

肿瘤靶向治疗基因检测临床应用结果

肿瘤抑制基因 (TSG) 是癌症发展过程中必不可少的基因。虽然它们在正常细胞中具有许多作用，但 TSG 的突变和失调会导致癌细胞中的异常分子过程。因此，了解 TSG 及其在致癌过程中的作用对于预防和治疗癌症至关重要。在这项研究中，多组学乳腺癌数据被用于确定 TSG 在乳腺癌中的分子机制。在来自公共存储库的四个大规模转录组学数据中通过基因检不则鉴定了差异表达基因和差异共表达基因，并对拷贝数、甲基化和基因表达进行了多组学数据分析。使用 p 值求和方法的富集分析和荟萃分析对分析结果进行整合。综合分析表明，肿瘤抑制基因与与细胞周期、基因组稳定性、RNA加工和转移有关的基因本体术语的基因具有显着的关系，表明了肿瘤抑制基因对癌细胞的调控机制。该分析框架和基因检测研究结果将为进一步鉴定不同类型癌症中的肿瘤抑制基因提供有价值的信息。多组学数据；监管机制；抑癌基因。

肿瘤发生与复发转移国际数据库描述：

Tumor suppressor genes (肿瘤抑制基因) are essential genes in the development of cancer. While they have many roles in normal cells, mutation and dysregulation of the 肿瘤抑制基因 result in aberrant molecular processes in cancer cells. Therefore, understanding 肿瘤抑制基因 and their roles in the oncogenic process is crucial for prevention and treatment of cancer. In this research, multi-omics breast cancer data were used to identify molecular mechanisms of 肿瘤抑制基因 in breast cancer. Differentially expressed genes and differentially coexpressed genes were identified in four large-scale transcriptomics data from public repositories and multi-omics data analyses of copy number, methylation and gene expression were performed. The results of the analyses were integrated using enrichment analysis and meta-analysis of a p-value summation method. The integrative analysis revealed that 肿瘤抑制基因 have a significant relationship with genes of gene ontology terms that are related to cell cycle, genome stability, RNA processing and metastasis, indicating the regulatory mechanisms of 肿瘤抑制基因 on cancer cells. The analysis frame and research results will provide valuable information for the further identification of 肿瘤抑制基因 in different types of cancers.Keywords: breast cancer; multi-omics data; regulatory mechanism; tumor suppressor gene.

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