【佳学基因检测】将基因检测结果、信息分析和基因组学的见解转化为精准精神病学的具体实施方案

基因检测多少钱一次1万八解剖

与专家交流神经系统个性化药物研究路径发现《Genome Med》在. 2020 Apr 29;12(1):43.发表了一篇题目为《将神经精神遗传学和基因组学的见解转化为精准精神病学》神经精神学科的基因检测所获得的信息应用的临床研究文章。该研究由Elliott Rees, Michael J Owen等完成。成为基因检测方法改进、应用途径及学科教育的标杆性文章，对基因检测的必要性信及其在精准医疗中的方法学进行了全面介绍。

遗传力、发病原因及精准治疗临床研究内容关键词：

遗传学基因组风险评分；精神病学；精神分裂症。

精神科心理科疾病用药指导基因检测临床应用结果

精准医疗的主要目标是更贴近个体患者的需求来定制医疗保健。这需要在两个领域取得进展：开发更精确的治疗方法，以及识别临床中可能对这些治疗最有效的患者或患者群体的能力。人们普遍乐观地认为，基因组学的进步将促进这两项努力。可以说，鉴于精神病学目前对综合征诊断的依赖、现有机械知识的最小基础以及精神病学表型的大量遗传性，精神病学在所有医学专业中在这些方面获益最多。在这里，我们回顾了精神病学基因组学的最新进展，并评估了这些发现可能对开发精准精神病学的影响。新发现表明高度的多基因性，并且遗传风险很难映射到临床使用的诊断类别。精神遗传学的高度多基因和多效性将影响使用基因组数据进行预测和风险分层的尝试，并且也对从遗传发现中获得生物学见解的传统方法提出重大挑战。虽然有许多挑战需要克服，但基因组学正在建立一个经验平台，精神病学现在可以在此平台上更好地了解疾病机制、更好的治疗方法，以及更好地针对最有可能受益的患者进行靶向治疗，从而为精准治疗铺平道路精神病学。关键词：遗传学；基因组风险评分；精准精神病学；精神分裂症。

神经及精神疾病及其并发征、合并征国际数据库描述：

The primary aim of precision medicine is to tailor healthcare more closely to the needs of individual patients. This requires progress in two areas: the development of more precise treatments and the ability to identify patients or groups of patients in the clinic for whom such treatments are likely to be the most effective. There is widespread optimism that advances in genomics will facilitate both of these endeavors. It can be argued that of all medical specialties psychiatry has most to gain in these respects, given its current reliance on syndromic diagnoses, the minimal foundation of existing mechanistic knowledge, and the substantial heritability of psychiatric phenotypes. Here, we review recent advances in psychiatric genomics and assess the likely impact of these findings on attempts to develop precision psychiatry. Emerging findings indicate a high degree of polygenicity and that genetic risk maps poorly onto the diagnostic categories used in the clinic. The highly polygenic and pleiotropic nature of psychiatric genetics will impact attempts to use genomic data for prediction and risk stratification, and also poses substantial challenges for conventional approaches to gaining biological insights from genetic findings. While there are many challenges to overcome, genomics is building an empirical platform upon which psychiatry can now progress towards better understanding of disease mechanisms, better treatments, and better ways of targeting treatments to the patients most likely to benefit, thus paving the way for precision psychiatry.Keywords: Genetics; Genomic risk scores; Precision psychiatry; Schizophrenia.

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